GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs10461617 | 1 | rs1423621 | chr5:56101035 | C5orf35 | chr5:56205103-56213010:+ | 0.48 | 5.5 | 1.58E-7 | Type 2 diabetes |
| UCEC | cis | rs1432723 | 1 | rs1432723 | chr5:155302582 | PPP1R2P3 | chr5:156277549-156279539:+ | 0.42 | 4.66 | 6.73E-6 | Obesity-related traits |
| UCEC | cis | rs10935120 | 1 | rs1498718 | chr3:134205920 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.46 | 1.57E-5 | Height |
| UCEC | cis | rs30187 | 1 | rs151964 | chr5:96123666 | ERAP1 | chr5:96096515-96149837:- | -0.45 | -5.68 | 6.65E-8 | Ankylosing spondylitis |
| UCEC | cis | rs10935120 | 1 | rs1534026 | chr3:134284767 | ANAPC13 | chr3:134196547-134204865:- | 0.41 | 4.69 | 6.01E-6 | Height |
| UCEC | cis | rs9309473 | 1 | rs1534471 | chr2:73647508 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.21 | 4.94E-9 | Metabolite levels |
| UCEC | cis | rs10461617 | 1 | rs1559282 | chr5:56099375 | C5orf35 | chr5:56205103-56213010:+ | 0.47 | 5.58 | 1.06E-7 | Type 2 diabetes |
| UCEC | cis | rs2241437 | 1 | rs1561328 | chr2:86272758 | LOC90784 | chr2:86247339-86250991:- | -0.69 | -6.44 | 1.51E-9 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| UCEC | cis | rs9815354 | 1 | rs1564716 | chr3:41862613 | ULK4 | chr3:41288091-42003660:- | 0.45 | 5.21 | 6.03E-7 | Diastolic blood pressure |
| UCEC | cis | rs1570271 | 1 | rs1570271 | chr10:115288501 | C10orf118 | chr10:115881974-115934364:- | -0.33 | -4.43 | 1.76E-5 | Survival in rectal cancer |
| UCEC | cis | rs1577917 | 1 | rs1577917 | chr6:86691940 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -5.8 | 3.64E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs1577919 | chr6:86757296 | SNHG5 | chr6:86386726-86388451:- | -0.49 | -5.66 | 7.26E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs703842 | 1 | rs1599932 | chr12:58177943 | TSFM | chr12:58176536-58191367:+ | -0.45 | -4.76 | 4.48E-6 | Multiple sclerosis |
| UCEC | cis | rs9815354 | 1 | rs1607908 | chr3:41905196 | ULK4 | chr3:41288091-42003660:- | 0.53 | 6.52 | 9.73E-10 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs1612124 | chr3:41967893 | ULK4 | chr3:41288091-42003660:- | -0.4 | -4.77 | 4.27E-6 | Diastolic blood pressure |